The gold standard for diagnosing IgE-mediated allergies.
Medically reviewed by Dr. Sarah Jenkins, MD, FACAAI
Verified ReviewerBoard Certified Allergist & Immunologist · Clinical Allergy, Asthma & Immunology
Stanford University School of Medicine
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The skin prick test introduces a microscopic amount of allergen into the epidermis. A positive result is indicated by the formation of a 'wheal and flare' (a raised bump surrounded by redness), proving the presence of specific IgE antibodies attached to skin mast cells.
| Test Component | Purpose |
|---|---|
| Histamine Control | Proves the skin can react properly |
| Saline Control | Provides a baseline for non-reaction |
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Dr. Sarah Jenkins, MD, FACAAI
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Clinical Allergy, Asthma & Immunology
Dr. Michael Chen, MD, PhD
Clinical Immunologist & Researcher
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All contributors hold active board certification in allergy, immunology, or a related specialty. View full credentials →
Sampson HA, et al. "Second symposium on the definition and management of anaphylaxis: Summary report" — Journal of Allergy and Clinical Immunology.
View sourceAmerican College of Allergy, Asthma & Immunology (ACAAI) "Allergy Facts and Figures" — ACAAI Clinical Resources.
View sourceWorld Allergy Organization (WAO) "White Book on Allergy — 2025 Update" — World Allergy Organization.
View sourceNational Institute of Allergy and Infectious Diseases (NIAID) "Clinical Guidelines for the Diagnosis and Management of Food Allergy" — National Institutes of Health.
View sourceMuraro A, et al. "EAACI food allergy and anaphylaxis guidelines: Diagnosis and management of food allergy" — Allergy — European Journal of Allergy and Clinical Immunology.
This content reflects clinical guidelines current as of the last review date shown above. Always consult a qualified healthcare provider for personalized medical advice.